Milos Pekny Selected Research

desmuslin (synemin)

1/2014	Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease.
10/2013	Astrocytoma grade IV (glioblastoma multiforme) displays 3 subtypes with unique expression profiles of intermediate filament proteins.
7/2013	Intermediate filaments are important for astrocyte response to oxidative stress induced by oxygen-glucose deprivation and reperfusion.
4/2007	Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks.

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Milos Pekny Research Topics

Disease

17	Gliosis 01/2021 - 06/2005
11	Stroke (Strokes) 12/2021 - 11/2006
10	Ischemia 01/2021 - 03/2006
8	Inflammation (Inflammations) 01/2021 - 03/2006
5	Hypoxia (Hypoxemia) 01/2021 - 07/2004
4	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2014 - 08/2007
4	Hypertrophy 07/2013 - 05/2004
3	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 01/2013
3	Retinal Detachment (Retinal Detachments) 12/2015 - 06/2007
3	Alexander Disease (Alexander's Disease) 01/2014 - 11/2004
3	Astrocytoma (Pilocytic Astrocytoma) 10/2013 - 05/2003
2	Insulin Resistance 12/2021 - 12/2018
2	Neuroinflammatory Diseases 12/2021 - 01/2016
2	Brain Injuries (Brain Injury) 10/2021 - 09/2013
2	Chromosomal Instability (Chromosome Stability) 01/2019 - 07/2018
2	Atherosclerosis 01/2019 - 11/2018
2	Wounds and Injuries (Trauma) 07/2018 - 03/2014
2	Amyloid Plaque 06/2015 - 01/2013
2	Neoplasms (Cancer) 10/2013 - 05/2003
2	Brain Ischemia (Cerebral Ischemia) 01/2012 - 03/2008
2	Infarction (Infarctions) 01/2012 - 03/2008
2	Central Nervous System Diseases (CNS Diseases) 10/2011 - 08/2003
1	Atrophy 12/2021
1	Weight Loss (Weight Reduction) 12/2021
1	Thrombosis (Thrombus) 10/2021
1	Asphyxia (Suffocation) 01/2021
1	Cognitive Dysfunction 01/2021
1	Fibrosis (Cirrhosis) 01/2019
1	Lung Injury 01/2019
1	Body Weight (Weight, Body) 01/2019
1	Glaucoma 01/2017
1	Brain Neoplasms (Brain Tumor) 04/2016
1	Glioblastoma (Glioblastoma Multiforme) 10/2013
1	Brain Diseases (Brain Disorder) 09/2013
1	Sciatic Neuropathy (Lesion of Sciatic Nerve) 01/2013
1	Wallerian Degeneration 01/2013
1	Ischemic Stroke 08/2010

Drug/Important Bio-Agent (IBA)

22	VimentinIBA 01/2019 - 05/2004
18	Glial Fibrillary Acidic ProteinIBA 01/2019 - 05/2003
16	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2004
8	Complement System Proteins (Complement)IBA 01/2021 - 03/2006
8	Intermediate Filament ProteinsIBA 01/2019 - 05/2004
6	NestinIBA 10/2013 - 11/2006
4	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 07/2013
4	Peptides (Polypeptides)IBA 01/2021 - 11/2009
4	Retinaldehyde (Retinal)IBA 12/2015 - 07/2004
4	desmuslin (synemin)IBA 01/2014 - 04/2007
3	Oxygen (Dioxygen)IBA 01/2019 - 07/2013
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2021
2	Serine (L-Serine)FDA Link 01/2019 - 07/2018
2	CytokinesIBA 01/2016 - 08/2010
2	Neuroprotective AgentsIBA 01/2012 - 01/2007
2	Plasminogen Activator Inhibitor 1IBA 08/2010 - 03/2008
1	ParvalbuminsIBA 12/2021
1	complement C3a receptorIBA 10/2021
1	Insulin Receptor Substrate ProteinsIBA 12/2018
1	LipidsIBA 11/2018
1	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 01/2016
1	Arginine (L-Arginine)FDA Link 01/2016
1	Caspase 3 (Caspase-3)IBA 01/2016
1	Chondroitin Sulfate ProteoglycansIBA 12/2014
1	Rose BengalIBA 12/2014
1	Heparin (Liquaemin)FDA LinkGeneric 03/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2014
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 03/2014
1	Epidermal Growth Factor (EGF)IBA 03/2014
1	Crystallins (Crystallin)IBA 01/2014
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2014
1	Biological ProductsIBA 10/2013
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2013
1	Amyloid (Amyloid Fibrils)IBA 01/2013
1	thrombospondin 4IBA 01/2013
1	AntigensIBA 06/2012
1	AntioxidantsIBA 01/2012
1	sulforaphaneIBA 01/2012
1	NF-E2 Transcription FactorIBA 01/2012
1	Plasminogen Activators (Plasminogen Activator)IBA 08/2010
1	Transforming Growth Factor alpha (TGF-alpha)IBA 08/2010
1	Interleukin-10 (Interleukin 10)IBA 08/2010
1	Interleukin-6 (Interleukin 6)IBA 08/2010
1	SerpinsIBA 08/2010
1	Peptide Hydrolases (Proteases)FDA Link 08/2010
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 08/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2010
1	Messenger RNA (mRNA)IBA 08/2010
1	Transforming Growth Factor beta (TGF-beta)IBA 08/2010
1	Serine Proteases (Serine Protease)IBA 08/2010
1	AnaphylatoxinsIBA 11/2009
1	Glutamic Acid (Glutamate)FDA Link 03/2008
1	Endothelin B ReceptorIBA 03/2008
1	ProteomeIBA 09/2007
1	Protein Isoforms (Isoforms)IBA 09/2007
1	14-3-3 Proteins (14-3-3 Protein)IBA 09/2007

Therapy/Procedure

8	Therapeutics 10/2021 - 08/2003
2	Transplantation 01/2018 - 08/2003
1	Intranasal Administration 01/2021
1	Nephrectomy 01/2019
1	Music Therapy 01/2017
1	Radiotherapy 04/2016
1	Axotomy 01/2013